发明名称 |
GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF |
摘要 |
An in-vitro method of activating T cells is disclosed. The method comprises incubating T cells with pathogenic cells in the presence of a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of PLIF to human leukocytes under conditions which allow expansion of the T cells. |
申请公布号 |
EP2950808(A1) |
申请公布日期 |
2015.12.09 |
申请号 |
EP20140745808 |
申请日期 |
2014.02.03 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD. |
发明人 |
MOROZ, CHAYA;SOLODEEV, INNA |
分类号 |
A61K38/19;A61P35/02;A61P37/04;C12N5/0783 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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