| 发明名称 | Quinoline derivatives as AXL kinase inhibitors | ||
| 摘要 | Novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family are described herein. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunction of a receptor of the AXL family. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly cancer metastases. | ||
| 申请公布号 | US9206130(B2) | 申请公布日期 | 2015.12.08 |
| 申请号 | US200912933070 | 申请日期 | 2009.04.16 |
| 申请人 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V. | 发明人 | Ullrich Axel;Knyazev Pjotr;Zhang Yixiang;György Kéri;Örfi László;Szabadkai István |
| 分类号 | C07D413/12;C07D409/12;C07D405/12;C07D401/12;C07D215/20 | 主分类号 | C07D413/12 |
| 代理机构 | Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C. | 代理人 | Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C. ;Meyertons Eric B. |
| 主权项 | 1. Compounds of the formula (I): wherein R1 is hydrogen;R2 is fluorine, or methoxy;R3 is hydrogen, benzyloxy, methoxy, 3-amino-propoxy, 2-morpholin-4-yl-ethoxy, 3-(4-methyl-piperidin-1-yl)-propoxy, 3-(3-methyl-piperidin-1-yl)-propoxy, or 3-morpholin-4-yl-propoxy;R4 is hydrogen, or —CF3; R5 is hydrogen, or —CH3;R6 is hydrogen; R7, R8, R9 and R10, which may be the same or different, represent a hydrogen atom, halogen, C1-6 alkyl, and/or C1-6 alkoxy,R11 represents a saturated or unsaturated three- to twelve-membered carbocyclic or heterocyclic ring system which is optionally substituted, R15 represents hydrogen; orpharmaceutically acceptable salts thereof. | ||
| 地址 | Müchen DE | ||