Layer processing for pharmaceuticals

摘要

Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.

主权项

1. A method for manufacturing an article comprising an ingestible pharmaceutical product or a precursor thereof, comprising:
producing a pharmaceutically active composition from a precursor by reacting the precursor within a fluid to form the pharmaceutically active composition; depositing the fluid comprising the pharmaceutically active composition on a substrate; forming a layer comprising the pharmaceutically active composition, the layer having an elongated dimension; manipulating the layer about its elongated dimension to form the article, wherein an average thickness of the article is at least about two times an average thickness of portions of the layer used to form the article; and bonding adjacent portions of the layer into a unitary structure, wherein forming the layer comprising the pharmaceutically active composition comprises removing material deposited with the fluid from the substrate.