| 发明名称 |
Nucleic acid molecule encoding target antibodies directed to DLL4 |
| 摘要 |
The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics. |
| 申请公布号 |
US9206255(B2) |
申请公布日期 |
2015.12.08 |
| 申请号 |
US201414168387 |
申请日期 |
2014.01.30 |
| 申请人 |
MEDIMMUNE, LLC |
发明人 |
Foltz Ian;Jenkins David;Bedian Vahe |
| 分类号 |
C07H21/04;A61K39/395;C07K16/18;C07K16/22;C07K16/28;C07K14/435;C07K14/475;A61K39/00 |
主分类号 |
C07H21/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated nucleic acid molecule encoding an antibody or binding fragment thereof that specifically binds to Delta-like ligand 4 (DLL4), wherein the antibody comprises:
(a) a heavy chain variable region (VH) CDR1, CDR2 and CDR3 of SEQ ID NO:30 or SEQ ID NO:75; and (b) a light chain variable region (VL) CDR1, CDR2 and CDR3 of SEQ ID NO:32, SEQ ID NO:50 or SEQ ID NO:76. |
| 地址 |
Gaithersburg MD US |
