| 主权项 |
1. A compound according to the Formula (II) or a pharmaceutically acceptable salt thereof; wherein R1 and R2 are independently hydrogen or are independently selected from the group consisting of C1-C6alkyl, C1-C6alkoxy and C3-C7cycloalkylC0-C2alkyl, each of which is substituted with 0, 1, or 2 residues selected from halogen and C1-C4alkyl; R3 is C1-C6alkyl or C2-C6alkenyl; R4 is C1-C8alkyl, C3-C8cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O or S, each of which is substituted with 0-2 C1-C4 alkyl groups; J is a bond or a divalent residue of the formula: R5 is C1-C8alkyl, C3-C8cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O or S, each of which is substituted with 0-2 C1-C4 alkyl groups; R6 is hydrogen or C1-C4alkyl; G is a group of the formula -E-R7; E is a bond, CH2, C(O), S(O)2, C(R9)2C(O), or C(O)C(R9)2, R7 is selected from the group consisting of C1-C6alkyl, haloC1-C6alkyl, C3-C7cycloalkylC0-C2alkyl, C1-C6alkoxy, haloC1-C6alkoxy, C3-C7cycloalkylC0-C2alkoxy, mono- and di-C1-C6alkylamino, —S(O)2R10, —N(R9)S(O)2R10, monocyclic or bicyclic heterocycle, and monocyclic or bicyclic aryl, wherein each residue is unsubstituted or substituted with 1, 2, or 3 R8 groups each of which R8 residues is independently selected from the group consisting of C1-C6alkyl, and C1-C6alkanoyl; or R6 and R7, taken in combination with the N atom to which they are attached, forms a 4 to 7 membered heterocyclic ring having 0, 1, or 2 additional ring heteroatoms selected from N, O or S and which ring is substituted by 0, 1, 2 or 3 substituents which are independently selected from the group consisting of oxo, C1-C4alkyl, halo C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, hydroxyl, C1-C4alkoxy, haloC1-C4alkoxy, amino, mono- and di-C1-4alkylamino, aminoC1-C4alkyl, C1-C4alkanoylaminoC1-C4alkyl; R9 is independently selected at each occurrence from hydrogen and C1-C4alkyl; R10 is C1-C6alkyl, amino or mono- and di-C1-C6alkylamino; and pharmaceutically acceptable salts, hydrates, and solvates thereof. |
