Inhibitors of anaphase promoting complex activity

摘要

The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibiting the ubiquitination activity of the APC by administering compositions of the invention.

主权项

1. A method for inhibiting a ubiquitination activity of an APC in a mammalian cell comprising a spindle assembly checkpoint (SAC), comprising administering an effective amount of a non-peptide analog of a C-terminal IR motif of an activator of an APC to a mammalian cell to inhibit a degradation of a substrate of an APC.