Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated conditions

摘要

Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided.

主权项

1. An aptamer that specifically binds IL-6, wherein the aptamer comprises a sequence selected from:(SEQ ID NO: 705)5′-YXAXGYARQaMGYAAGSCGRY-3′ (VI);and(SEQ ID NO: 706)5′-MGYAAGSCGRYQbYXAXGYAR-3′ (VII); wherein each Y is independently selected from a modified pyrimidine; each X is independently selected from a modified pyrimidine; M is selected from C and A; S is selected from C and G; each R is independently selected from G and A; each Q is independently selected from a linker, a modified nucleotide, and an unmodified nucleotide; a is 1 to 30; and / or b is 1 to 30.