| 主权项 |
1. A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein: Z is ═C(R2)— or ═N—; ring A is phenyl, a monocyclic 5-6 membered heteroaryl comprising 1 to 3 hetero ring atoms independently selected from N, O and S, a carbocyclic comprising 4 or more ring atoms, or a heterocyclic, wherein ring A is optionally substituted with one or more R6; each R1 and R2 is independently selected from hydrogen, halo, —OH, —CN, C1-C4 alkyl, —O—(C1-C4 alkyl), N(R7)2, —(C0-C4 alkylene)-aryl, —(C0-C4 alkylene) -heteroaryl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-carbocyclyl, —O—(C0-C4 alkylene)-aryl, —O—(C0-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-heterocyclyl, and —O—(C0-C4 alkylene)-carbocyclyl; or
one R1 and R2 are taken together with atoms to which they are bound to form an aryl, heteroaryl, heterocyclyl, or carbocyclyl; each of R3a, R3b, and R3c is independently selected from hydrogen, halo, —OH, —CN, C1-C4 alkyl, C2-C4 alkenyl or alkynyl, —O—(C1-C4 alkyl), N(R7)2, —(C0-C4 alkylene)-aryl, —(C0-C4 alkylene) -heteroaryl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-carbocyclyl, —O—(C0-C4 alkylene)-aryl, —O—(C0-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-heterocyclyl, —O—(C0-C4 alkylene)-carbocyclyl, —C(O)OR9, —C(O)N(R9)2, —S(O)R8, —S(O)2R8 and —S(O)2N(R9)2; each L1 is independently selected from —C(R4)2—, —C(R4)═C(R4)—, —C≡C—, —O—, —S—, —S(O)—, —S(O)2, and —N(R5)—; or
any L1 is optionally taken together with R3a and any intervening atoms to form a fused aryl, heteroaryl, heterocyclyl or carbocyclyl ring; wherein when ring A is phenyl, a 5-6 membered heteroaryl, or a heterocyclyl bound to L1 through a ring nitrogen atom, then n is an integer from 1 to 6; each R4 is independently selected from hydrogen, halo, C1-C4 alkyl, —CH2OH, —OH, —(C0-C4 alkylene)-O—(C1-C4 alkyl), —(C0-C4 alkylene)-N(R7)2, and —CN; or
two R4 are taken together with a common carbon atom to which they are both bound to form a carbocyclic, heterocyclic, or =0; ortwo R4 bound to different carbon atoms are taken together with the different carbon atoms and any intervening atoms to form a carbocyclic, or heterocyclic; R5 is selected from hydrogen, C1-C4 alkyl, and C2-C4 haloalkyl; or
R4 and R5 are taken together with the atoms to which they are bound and any intervening atoms to form a heterocyclic; each R6 is independently selected from halo, —CN, ═O, —(C1-C4 alkylene)-O—R8, —(C0-C4 alkylene)-O—(C0-C4 alkylene)-R9, —(C0-C4 alkylene)-N(R7)2, —(C0-C4 alkylene)-R8, —(C0-C4 alkylene)-C(O)—O—R9, —(C0-C4 alkylene)-O—C(O)—R9, —(C0-C4 alkylene)-C(O)—N(R9)2, —(C0-C4 alkylene)-S(O)—R8, —(C0-C4 alkylene)-S(O)2—R8 and —(C0-C4 alkylene)-S(O)2—N(R9)2; or
two R6 bound to adjacent atoms in ring A are taken together with the atoms to which they are bound to form a monocyclic aryl, heteroaryl, heterocyclyl, or carbocyclyl; each R7 is independently selected from hydrogen, —(C0-C4 alkylene)-R9, —(C2-C4 alkylene)-O—R8, C2-C4 haloalkyl, —S(O)2—R8, —C(═O)—R8, —C(═O)—N(R9)(R9), —(C2-C4 alkylene)-O—C(═O)—R8 and —(C0-C4 alkylene)-C(═O)—O—R9; or
two R7 are taken together with the nitrogen atom to which they are commonly bound to form an optionally substituted heterocyclyl or heteroaryl; R8 is selected from C1-C4 alkyl, aryl, heteroaryl, carbocyclyl and heterocyclyl; each R9 is independently selected from hydrogen and R8; represents a single or double bond; n is 0 or an integer from 1 to 6; wherein any portion of the compound designated as alkyl, alkylene, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl or carbocyclyl is optionally substituted; and each ring of any aryl, heteroaryl, heterocyclyl or carbocyclyl has not more than three substituents per ring. |
