发明名称 |
Transmucosal delivery system |
摘要 |
This invention relates to a multi-configured, transmucosal pharmaceutical dosage form and, more particularly, to a pharmaceutical dosage form which has a single monolithic/heterogeneous layer or a plurality of such layers. The dosage form is suitable for the delivery of one or more pharmaceutical compositions via the buccal, sublingual, rectal, vaginal or transmucosal delivery route in a human or animal body. It provides for selected delivery profiles resulting from, but not limited to, a porosity-enabled composite matrix of one or more layers/components of the pharmaceutical composition/s. The invention also provides for a method of manufacturing said transmucosal pharmaceutical dosage form in a plurality of configurations. |
申请公布号 |
US9205049(B2) |
申请公布日期 |
2015.12.08 |
申请号 |
US200912999911 |
申请日期 |
2009.06.03 |
申请人 |
University of the Witwatersrand, Johannesburg |
发明人 |
Reddy Deshika;Adeleke Oluwatoyin Ayotomilola;Pillay Viness;Choonara Yahya |
分类号 |
A61K9/14;A61K9/00;A61K9/19;A61K31/135 |
主分类号 |
A61K9/14 |
代理机构 |
Hamilton, Brook, Smith & Reynolds, P.C. |
代理人 |
Hamilton, Brook, Smith & Reynolds, P.C. |
主权项 |
1. A bilayered transmucosal buccal pharmaceutical dosage form, wherein the dosage form consists of:
a porous cellulosic layer that forms a gel upon contact with a bodily fluid, the gel forming a diffusive barrier; and a granular layer of chitosan that disintegrates more rapidly than the cellulosic layer upon contact with the bodily fluid; and a pharmaceutically active compound, wherein the pharmaceutical dosage form delivers the pharmaceutically active compound to a buccal mucosal surface, wherein the cellulosic layer and the granular layer are crosslinked with a crosslinking agent selected from a metal salt or a salt of the Hofmeister series of salts. |
地址 |
Braamfontein, Johannesburg ZA |