| 主权项 |
1. At least one compound of formula (I): or at least one pharmaceutically acceptable salt thereof, wherein: each R1 is independently:
hydrogen,halogen,hydroxyl,C1-10 alkyl,C3-10 cycloalkyl,C3-10 cycloalkyl-alkyl,heterocyclyl,heterocyclylalkylaryl,arylalkyl,heteroaryl, orheteroarylalkyl,wherein alkyl, cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent independently selected from R6a, and wherein aryl and heteroaryl are each unsubstituted or substituted with at least one substituent independently selected from R6b; each R2 is independently:
C1-10 alkyl or piperidinyl,wherein alkyl and piperidinyl are each unsubstituted or substituted with at least one substituent independently selected from R6a; each R3 is independently:
hydrogen,halogen,—CN,—NR7R8, orC1-10 alkyl;wherein alkyl is unsubstituted or substituted with at least one substituent independently selected from R6a; each R4 is independently:
hydrogen,halogen,—CN,C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl, orC3-10 cycloalkyl;wherein C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, and C3-10 cycloalkyl are each unsubstituted or substituted with at least one substituent independently selected from R6a; or R3 and R4 together with the carbon atoms to which they are attached form a 5-6 membered ring containing 0, 1, 2 or 3 heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen, and optionally substituted with 1-2 R6b groups; each R5 is independently:
C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl,C3-10 cycloalkyl,—OR8,—NR7S(O)rR8,—NO2,halogen,—S(O)rR7,—SR8,—S(O)2OR7,—OS(O)2R8,—S(O)rNR7R8,—NR7R8,—O(CR9R10)tNR7R8,—C(O)R7,—CO2R8,—CO2(CR9R10)tCONR7R8,—OC(O)R7,—CN,—C(O)NR7R8,—NR7C(O)R8,—OC(O)NR7R8,—NR7C(O)OR8,—NR7C(O)NR7R8,—CR7(N—OR8),—CHF2,—CF3,—OCHF2, or—OCF3;wherein C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, and C3-10 cycloalkyl are each unsubstituted or substituted with at least one substituent independently selected from R6a; each R6a is independently:
C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl,C3-10 cycloalkyl,—OR8,—NR7S(O)rR8,—NO2,halogen,—S(O)rR7,—SR8,—S(O)2OR7,—OS(O)2R8,—S(O)rNR7R8,—NR7R8,—(CR9R10)tOR8,—(CR9R10)tNR7R8,—(CR9R10)tSR8,—(CR9R10)tS(O)rR8,—(CR9R10)tCO2R8,—(CR9R10)tCONR7R8,—(CR9R10)tNR7CO2R8,—(CR9R10)tOCONR7R8,—(CR9R10)tNR7CONR7R8,—(CR9R10)tNR7SO2NR7R8,—O(CR9R10)tNR7R8,—C(O)R7,—C(O)(CR9R10)tOR8,—C(O)(CR9R10)tNR7R8,—C(O)(CR9R10)tSR8,—C(O)(CR9R10)tS(O)rR8,—CO2R8,—CO2(CR9R10)tCONR7R8,—OC(O)R7,—CN,—C(O)NR7R8,—NR7C(O)R8,—OC(O)NR7R8,—NR7C(O)OR8,—NR7C(O)NR7R8,—CR7(N—OR8),—CHF2,—CF3,—OCHF2, or—OCF3; each R6b is independently:
R6a,aryl,aryl-C1-4 alkyl,heteroaryl, orheteroaryl-C1-4 alkyl; each R7 and each Ware independently:
hydrogen,C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl,C3-10 cycloalkyl,cycloalkyl-C1-10 alkyl;heterocyclyl,heterocyclyl-C1-10 alkyl,aryl,heteroaryl,aryl-C1-10 alkyl, orheteroaryl-C1-10 alkyl;wherein alkyl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent independently selected from R6a, and aryl and heteroaryl are each unsubstituted or substituted with at least one substituent independently selected from R6b; or R7 and R8 together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0, 1, or 2 additional heteroatoms independently selected from the group consisting of oxygen, sulfur and NR11, each R7 and R8 may be unsubstituted or substituted on a carbon or nitrogen atom with at least one substituent independently selected from R12; each R9 and each R10 are independently:
hydrogen,C1-10 alkyl,C2-10 alkenyl,C2-10 alkynyl,C3-10 cycloalkyl,cycloalkyl-C1-10 alkyl,heterocyclyl,heterocyclyl-C1-10 alkyl,aryl,heteroaryl,aryl-C1-10 alkyl, orheteroaryl-C1-10 alkyl; or R9 and R19 together with the carbon to which they are attached form a ring of 3 to 7 members containing 0, 1, or 2 heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen; each R11 is independently:
hydrogen,C1-10 alkyl,C3-10 cycloalkyl,C3-10 cycloalkyl-C1-4 alkyl,heterocyclyl,heterocyclyl-C1-4 alkyl,aryl,aryl-C1-4 alkyl,heteroaryl,heteroaryl-C1-4 alkyl,—S(O)rR7,—C(O)R7,—CO2R7,—CO2(CR9R10)tCONR7R8, or—C(O)NR7R8; each R12 is independently:
halogen,C1-10 alkyl,C3-10 cycloalkyl,C3-10 cycloalkylalkyl,heterocyclyl,heterocyclylalkyl,aryl,aryl-C1-4 alkyl,heteroaryl,heteroaryl-C1-4 alkyl,—OR7,—NR7S(O)rR8,—S(O)rR7,—SR7,—S(O)2OR7,—OS(O)2R7,—S(O)rNR7R8,—NR7R8,—O(CR9R10)tNR7R8,—C(O)R7,—CO2R8,—CO2(CR9R10)tCONR7R8,—OC(O)R7,—CN,—C(O)NR7R8,—NR7C(O)R8,—OC(O)NR7R8,—NR7C(O)OR8,—NR7C(O)NR7R8,—CHF2,—CF3,—OCHF2, or—OCF3;each m is independently 0, 1, or 2;each n is independently 1, 2, or 3;each p is independently 2;each q is independently 0, 1, 2, or 3;each r is independently 1 or 2;each t is independently 1, 2, or 3. |
