Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions

摘要

Novel antimicrobial compositions and coatings are disclosed. The antimicrobial compositions consist of mixtures of taurolidine and protamine, including protamine salts. The antimicrobial compositions are particularly useful in coatings for implantable medical devices. The antimicrobial compositions are effective against a broad spectrum of microbes.

主权项

1. A coated medical device, comprising:
a medical device having at least one surface; and, an antimicrobial coating on at least a part of said surface, wherein the coating comprises about 0.1 wt. % to about 10 wt. % of an antimicrobial composition, the composition comprising: about 50 wt. % to about 99 wt. % of taurolidine; and, about 1 wt. % to about 50 wt. % of protamine, wherein the antimicrobial composition has a synergistic index (SI) of greater than 1.