Bone graft substitute in the form of an implantable three-dimensional scaffold and method of manufacturing same

摘要

A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.

主权项

1. A bone graft substitute in the form of an implantable three-dimensional scaffold comprising calcium phosphate and having pores, wherein:
(i) the scaffold is impregnated with a calcium and/or phosphate containing substance, said calcium and/or phosphate containing substance having a solubility in an aqueous solution having a physiological ionic strength and a pH of 7.4 at 37° C. in a range between 2 mM and 1 M; (ii) a dissolution rate DRS of said scaffold is slower than a dissolution rate DRD of said calcium and/or phosphate containing substance used to impregnate the scaffold; (iii) a chemical composition and integrity of the scaffold remains essentially unaffected by said impregnation with said calcium and/or phosphate containing substance; and (iv) a degree of porosity of said scaffold is in a range of 40% to 95%.