Antibodies and other molecules that bind B7-H1 and PD-1

摘要

The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.

主权项

1. An antibody or an antigen-binding fragment thereof comprising six complementarity determining regions (CDRs),
wherein the CDRs comprise the three light chain CDRs of SEQ ID NO:98 and the three heavy chain CDRs of SEQ ID NO:106, and wherein the antibody or antigen-binding fragment thereof immunospecifically binds PD-1.