Dextrin hydrogel for biomedical applications

摘要

A hydrogel formulation of oxidized dextrin is reticulated with adipic acid dihydrazide, which may embody polysaccharides, proteins, nanogels, granular materials, bioactive molecules and cells for tissue regeneration and controlled drug delivery. A hydrogel can be injectable, highly biocompatible and biodegradable, for tissue regenerative applications, performing simultaneously as a vehicle e.g. for nanogels, granular materials and cells, and as controlled drug delivery systems, e.g. of hydrophobic molecules and therapeutic proteins.

主权项

1. A hydrogel formulation comprising a hydrogel of oxidized dextrin reticulated with adipic acid dihydrazide comprising the following structure:wherein the hydrogel comprises a three-dimensional porous structure, and wherein the three-dimensional porous structure is capable of enclosing polysaccharides, proteins, nanogels, nanoparticles, granular materials, bioactive molecules and/or cells, and wherein the dextrin has a molecular weight between 1200 and 8000 Da.