Biocatalysts with enhanced inhibitor tolerance

摘要

Disclosed herein are biocatalysts for the production of biofuels, including microorganisms that contain genetic modifications conferring tolerance to growth and fermentation inhibitors found in many cellulosic feedstocks. Methods of converting cellulose-containing materials to fuels and chemicals, as well as methods of fermenting sugars to fuels and chemicals, using these biocatalysts are also disclosed.

主权项

1. A microorganism of the genus Zymomonas comprising a genetic modification that increases the growth rate or biofuel production rate of the modified microorganism in the presence of a feedstock inhibitor compound relative to the growth rate or biofuel production rate of the unmodified microorganism wherein the genetic modification increases the expression or activity of a histidine kinase relative to the expression or activity level in the unmodified microorganism.