Arsenic compounds, their preparation methods and uses thereof

摘要

Arsenic compounds of general formula (I), their preparation methods, the pharmaceutical compositions containing the compounds, and their uses in the manufacture of medicaments for treating cancer, particularly leukemia, are disclosed.;

主权项

1. An arsenic compound having a structure of formula (I) or a levoisomer, a dextroisomer or a racemate thereof:wherein R1 is independently H, a linear or branched C2-C20 alkylacyl group, or a C7-C12 phenylalkylacyl group;
R2 is independently H, a linear or branched C2-C8 alkyl group, or a C7-C12 phenylalkyl group; and X is selected from the group consisting of H2AsO4−, HLiAsO4−, HKAsO4−, HNaAsO4−, Li2AsO4−, K2AsO4−, Na2AsO4−, CaAsO4−, MgAsO4−, AsO2−, (NH4)2AsO4−, and (NH4)HAsO4−.