| 发明名称 | Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof | ||
| 摘要 | Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels. | ||
| 申请公布号 | US9206426(B2) | 申请公布日期 | 2015.12.08 |
| 申请号 | US201113582921 | 申请日期 | 2011.03.07 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Manley James L.;Chen Mo;David Charles;Zhang Jian |
| 分类号 | A61K31/70;C07H21/02;C07H21/04;C12N15/113;A61K31/7105;A61K31/713;C12Q1/68 | 主分类号 | A61K31/70 |
| 代理机构 | Wilmer Cutler Pickering Hale and Dorr LLP | 代理人 | Wilmer Cutler Pickering Hale and Dorr LLP |
| 主权项 | 1. A method to reduce cell growth of a cancer cell comprising contacting a cancer cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB, wherein the inhibitory RNA molecule targeting hnRNPA1 comprises SEQ ID NO: 9 or is encoded by SEQ ID NO: 64, the inhibitory RNA molecule targeting hnRNPA2 comprises SEQ ID NO: 10 or is encoded by SEQ ID NO: 65, and the inhibitory RNA molecule targeting PTB comprises SEQ ID NO: 11 or is encoded by SEQ ID NO: 63. | ||
| 地址 | New York NY US | ||