ORGANOPHOSPHOROUS HYDROLASE VARIENT AND METHOD FOR PREPARING THEREOF

摘要

The present invention relates to a mutant organophosphate nerve agent hydrolase and, more specifically, to a mutant in which activity is more increased in a mutant organophosphate hydrolase (OPH). The present invention further relates to a production method thereof. The mutant OPH according to the present invention has high degradability for a nerve agent VX (O-ethyl-S-diisopropyl amino methylphosphonothiolate) which has shown low degradability in a wild type organophosphate-based compound hydrolase, thereby reducing loss of lives caused by the nerve agent used in chemical, biological, and radiological warfare.