METHOD FOR THE ISOLATION, PURIFICATION AND AMPLIFICATION OF RENAL PROGENITORS CD133+CD24+ FROM THE URINE OF PATIENTS SUFFERING FROM RENAL DISEASES

摘要

The present invention describes a non-invasive method to isolate with high efficiency, purity and reproducibility the population of renal progenitors CD133+CD24+, from urine samples of patients suffering from various glomerular diseases. Said renal progenitors can then easily be induced to differentiate into podocytes. The isolation of renal progenitors with the method of the invention allows the use of said cells as a cellular model of a disease for the in vitro study of genetic mutations due to the podocyte or for the study of renal toxicity induced by potentially nephrotoxic drugs on the tubules.