METHOD FOR ALL CANCER CATEGORY DETERMINATION BY MEANS OF METHYLATION PROFILING

摘要

A method for determining whether a patient belongs to a specific cancer category is disclosed, which method comprises, in a sample from said patient, performing an analysis to determine the DNA methylation level in a group of predetermined CpG sites; said group of predetermined CpG sites comprising in the range of 7- 50 CpG sites, and said group of predetermined CpG sites being associated with a specific cancer category, wherein the output of said analysis is a patient methylation profile comprising a patient-specific methylation level for each CpG site in said group of predetermined CpG sites, and wherein said specific cancer category is characterised by a cancer category methylation profile comprising a cancer category specific methylation level for each CpG site in said group of predetermined CpG sites, said method further comprising the step of comparing said patient methylation profile with said cancer category methylation profile, wherein said patient belongs to said specific cancer category if said patient methylation profile corresponds to said cancer category methylation profile.