| 发明名称 |
METHOD AND COMPOSITION FOR TREATING SPASTICITY |
| 摘要 |
The present invention provides a combined therapy for treating loss of GABA-mediated pre-synaptic inhibition after spinal injury. The therapeutic regimen includes spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) gene and administration of a GABA uptake inhibitor to modulate chronic spasticity in patients after spinal traumatic or ischemic injury. |
| 申请公布号 |
US2015343038(A1) |
申请公布日期 |
2015.12.03 |
| 申请号 |
US201414654886 |
申请日期 |
2014.01.22 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Marsala Martin |
| 分类号 |
A61K38/51;C12N7/00;A61K31/4535 |
主分类号 |
A61K38/51 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating spasticity in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a gamma-aminobutryic acid (GABA) uptake inhibitor in combination with upregulation of GAD65 (glutamate decarboxylase) gene, thereby treating spasticity in the subject. |
| 地址 |
Oakland CA US |
