| 主权项 |
1. A process for preparing a compound of formula (I): wherein Z is chosen from OH, O−, OR, SR, O(CO)OR, NH2, NHR, and NR2,
wherein R is chosen from linear or branched C1-7 alkyl, linear or branched C1-7 alkenyl or alkynyl, C3-7 cycloalkyl, and aryl-C0-4 alkyl, andwherein in NR2 the two R groups are optionally joined, forming a C2-10 alkyl or alkenyl ring; PG is a hydroxyl protecting group chosen from tetrahydropyranyl (THP), camphanoyl, bornyl, menthyl, R, (CO)R, CH2OR, CH2SR, and SiR3,
wherein R in SiR3 is the same or different, and is chosen from linear or branched C1-7 alkyl, linear or branched C1-7 alkenyl or alkynyl, C3-7 cycloalkyl, and aryl-C0-4 alkyl; and Q is chosen from the following radicals: wherein the symbol * specifies the bonding position; R1 is hydrogen or methyl; and R2 is chosen from hydrogen, methyl, hydroxyl, hydroxymethyl, and O-PG wherein, PG is as defined above; the process comprising reacting a compound of formula (II): wherein PG and Z are as defined for the compound of formula (I), with a compound of formula (III): wherein Q is as defined for the compound of formula (I). |
