COMPOSITIONS, METHODS AND USES FOR EXPRESSION OF ENTEROBACTERIUM-ASSOCIATED PEPTIDES

摘要

Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.

主权项

1. A modified vaccinia virus Ankara (MVA) nucleic acid sequence construct comprising:
a nucleic acid sequence of a live, attenuated or modified vaccinia Ankara (MVA) virus encoding: at least one virulence (V) antigen from a Yersinia spp.; at least one mammalian secretory signal sequence; and at least one translational control region.