METHODS OF TREATING SKIN DISORDERS USING IL-31RA ANTAGONIST

摘要

The present invention relates to methods of treating patients suffering from Contact dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia aereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination by administering an IL-31RA antagonist.

主权项

1. A method of treating a patient with a skin disorder selected from the group consisting of:
a) prurigo nodularis; b) Cutaneous T cell Lymphoma; c) Bullous pemphigoid; d) Vitiligo; e) Acne Rosacea; and f) Scleroderma; wherein the method comprises administering a therapeutically effective amount of a pharmaceutical composition comprising an anti-Interleukin-31RA (IL-31RA) antibody or an antigen-binding fragment thereof and a pharmaceutically acceptable carrier to the patient, wherein the anti-IL-31RA antibody or antigen-binding fragment binds amino acid residues 20-519 of SEQ ID NO:6.