VARIANT OF BPIFB4 PROTEIN

摘要

The present invention relates to a variant of BPIFB4 (Bactericidal/Permeability Increasing protein family B, member 4) protein and to its use for the treatment of pathologies involving impairment of nitric oxide signalling.

主权项

1. A BPIFB4 protein variant or fragment thereof, having an amino acid sequence with at least 85% homology to the amino acid sequence of SEQ ID NO: 1, said sequence comprising a Valine at the position corresponding to position 229 of SEQ ID NO: 1, a Threonine at the position corresponding to position 281 SEQ ID NO: 1, a Phenylalanine at a position corresponding to position 488 of SEQ ID NO: 1 and a Threonine at a position corresponding to position 494 of SEQ ID NO: 1.