PROCASPASE ACTIVATING COMPOUNDS

摘要

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds.

主权项

1. A compound of Formula (FX1):wherein
X1, X2, X3, X4, and X5 are each independently C or N, wherein when X1, X2, X3, X4, or X5 is N, the corresponding R10, R11, R12, R13, or R14 is absent; one of R10, R11, R12, R13, R14, R3, R7, R8, or R9 contains a polar group selected from the group consisting of: a sulfonamide group, a nitro group, an amino group, a carboxylate group, a sulfonyl group, and an aryl sulfonyl group; the others of R10, R11, R12, R13, R14, R3, R7, R8, or R9 are each independently selected from the group consisting of: hydrogen, halogen, a hydroxyl group, a sulfonamide group, a nitro group, an amino group, a carboxylate group, a sulfonyl group, an aryl sulfonyl group, an alkoxy group, C1-C6 alkyl, C1-C6 alkoxy, and C2-C6 alkenyl; n and m are each independently 1, 2 or 3; R4 and R5 are each independently CH or N; A is O or S; R6 is hydrogen or C1-C6 alkyl; X is oxygen; and R2 is hydrogen, C1-C6 alkyl, or C1-C6 alkoxy.