| 摘要 |
PROBLEM TO BE SOLVED: To provide novel compositions, cells and methods for assaying the activity of botulinum toxin A useful for various industries, such as pharmaceutical and food industries.SOLUTION: The present invention provides methods of making α-SNAP-25 antibodies that bind to an epitope comprising a carboxyl terminus at the P1 residue from the botulinum toxin serotype A (BoNT/A) cleavage site scissile bond from an SNAP-25 cleavage product. The antibodies specifically bind to peptides of specific sequences, and include light-chain CDRs of other specific sequences. The antibodies are used in BoNT/A activity assays. |
