| 主权项 |
1. A compound of formula (I): wherein, A is a 6 membered aryl or heteroaryl ring; X1 is CR2 or N; X2 and X3 are independently CR3 or N, provided that at most only one of X2 and X3 are N; R1 is selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —CN, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0*2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, wherein each C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl is optionally substituted with from one to five R20 groups; or R1 has the following structure: wherein B is selected from the group consisting of C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl; R2 is selected from the group consisting of H, C1-6 alkyl, C3-10 cycloalkyl, 3-12 membered heterocyclyl, C1-6 heteroalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —NRaRb, halogen, —CN, —NO2, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb and —NRaS(O)2Rb; each R3 is independently selected from the group consisting of H, C1-6 alkyl, C3-10 cycloalkyl, 3-12 membered heterocyclyl, C1-6 heteroalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —NRaRb, halogen, —CN, —NO2, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb and —NRaS(O)2Rb; each R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —NRaRb, halogen, C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, —NO2 and —ORa; R5 is selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, —NRaRb, halogen, C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 3-12 membered heterocyclyl and —O—R9, wherein each C1-6 alkyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with from one to five R20 groups; or R5 and one R4 are taken together to form a fused C6 aryl, 5-10 membered heteroaryl, 5-10 membered heterocyclyl or C3-6 cycloalkyl each optionally substituted with one to five R20 groups; R6 is —CN located at the meta (3) position with respect to the point of attachment of the A ring; R7 is selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, —NRaRb, halogen, C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, —NO2, —ORa, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with 1-5 R20 groups; each R8 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl, —NRaRb, halogen, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Rc, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, —NO2 and —ORa, wherein each C1-6 alkyl, C1-6 heteroalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl is optionally substituted with from one to five R20 groups; or R7 and R8 are taken together to form a fused, spiro or bridged C3-10 cycloalkyl or 3-12 membered heterocyclyl, which are optionally substituted with 1-5 R20 groups; R9 is C1-6 alkyl, 3-12 membered heterocyclyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl or 3-12 membered heterocyclyl, each of which is optionally substituted with from one to five R20 groups; n is 0-2; m is 0-3; each R20 is independently C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, halogen, oxo, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2, or two R20 groups can join together to form a fused, spiro or bridged C3-10 cylcloalkyl or 3-12 membered heterocyclyl ring, wherein each C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl is optionally substituted with from one to five halogen, oxo, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)0-2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2; each R21 is independently C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-C10 aryl, 5-10 membered heteroaryl, hydroxyl, amino, C1-6 alkylamino, —CN or halogen; and each Ra and Rb is independently H; or C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, each of which is optionally substituted with from one to five R21; or Ra and Rb together with the atoms to which they are attached form a 3-12 membered heterocyclyl optionally substituted with one to five R21 groups; with the proviso that if R1 is H, then all of R2 and R3 groups are H;or a pharmaceutically acceptable salt thereof. |
