| 发明名称 |
CHEMICALLY CLEAVABLE GROUP |
| 摘要 |
Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine. |
| 申请公布号 |
US2015344514(A1) |
申请公布日期 |
2015.12.03 |
| 申请号 |
US201314646619 |
申请日期 |
2013.11.22 |
| 申请人 |
TAGWORKS PHARMACEUTICALS B.V. |
发明人 |
Robillard Marc Stefan;Versteegen Ronny Mathieu;ten Hoeve Wolter;Rossin Raffaella |
| 分类号 |
C07H15/252;G01N33/543;C07C209/62;C07C45/61;C07C37/50;C07C205/20;C07C29/10;G01N33/60;C07C205/57 |
主分类号 |
C07H15/252 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. The use of a dienophile as a chemically cleavable group attached to a Construct, thereby provoking the release, in vitro, of the Construct by allowing the dienophile to react with a diene, wherein the dienophile is an eight-membered non-aromatic cyclic alkenylene group, preferably a cyclooctene group, and more preferably a trans-cyclooctene group. |
| 地址 |
Eindhoven NL |
