ARTEMISININ COMPOUNDS AND SYNTHESIS AND USE THEREOF

摘要

The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.

主权项

1. A compound having a structure wherein R1 is R2 is H, CH3, CCl3, CBr3, CF3, OH, NH, or R3 and R4 are each independently H, Cl, Br, I, F, CH3, CCl3, CBr3, CF3, a C1-C6 alkyl substituted with one or more Cl, Br, OH, or F, NO2, CH3OH, CH3CH2OH, OCH3, OCH2CH3, CO2, NH2, N(CH3)2, N(CCl3)2, N(CBr3)2, or N(CF3)2; R5 is H, OH, OCH3, or OCH2CH3; n is 0, 1, 2, 3, 4, or 5; m is 0, 1, 2, 3, 4, or 5; and X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently CH, N, O or S.