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A compound selected from the following:CpdStructureName732-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-9-(2-fluoro-phenyl)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin- 6-one722-(4-Chloro-3-methyl- phenylamino)-9-cyclopentyl-5- methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin- 6-one749-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)-7- ethyl-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin- 6-one752-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-methyl-9-phenyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6- one769-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5,7-dimethyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6- one854-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N,N-dimethyl- benzamide97N-Acetyl-4-(9-cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-methyl- benzenesulfonamide469-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)-5- methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin- 6-one1152-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-9-isopropyl-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin- 6-one404-(9-Cyclopentyl-7-ethyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide414-(9-Cyclopentyl-7-ethyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzoic acid424-(9-tert-Butyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide434-(9-tert-Butyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzoic acid444-[9-(3,4-Dimethoxy-benzyl)-5,7- dimethyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide454-[9-(3,4-Dimethoxy-benzyl)-5,7- dimethyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-benzoic acid479-Cyclopentyl-5-methyl-2-[4- (morpholine-4-sulfonyl)- phenylamino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one483-Methoxy-4-[9-(3-methoxy- phenyl)-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide494-[9-(3-Methoxy-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-benzoic acid504-[9-(2-Fluoro-phenyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzoic acid519-Cyclopentyl-5-methyl-2-(4- morpholin-4-yl-phenylamino)- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one524-[9-(2-Fluoro-phenyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-3-methoxy-N-(1- methyl-piperidin-4-yl)- benzamide533-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzenesulfonamide544-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzoic acid559-Cyclopentyl-2-(4- methanesulfonyl-phenylamino)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one563-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzoic acid573-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1-methyl- piperidin-4-yl)-benzamide584-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-2-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide594-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-ethoxy-N-(1- methyl-piperidin-4-yl)-benzamide609-Cyclopentyl-2-(2-methoxy- phenylamino)-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one614-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin- 4-yl)-benzenesulfonamide622-Benzylamino-9-cyclopentyl- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one634-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzenesulfonamide644-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1-methyl- piperidin-4-yl)-benzamide654-(9-Cyclopropylmethyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide664-(9-Butyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide674-(9-Isopropyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide683-Methoxy-4-[5-methyl-9-(3- methyl-butyl)-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide694-(9-Cyclopentylmethyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide 709-Cyclopentyl-5-methyl-2- phenylamino-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one719-Cyclopentyl-2-(2,4-dimethoxy- phenylamino)-5-methyl-5,7,8,9- tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one779-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5,7,7-trimethyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one78(9-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclopropane]792-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-9-(1-ethyl-propyl)-5- methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one809-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 8-isopropyl-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one812-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-methyl-9-(tetrahydro- pyran-4-yl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one829-Benzyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one834-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzamide844-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclopropane]-2- ylamino)-benzoic acid86N-[4-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzyl]-acetamide874-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- methyl-benzamide884-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N,N- dimethyl-benzamide894-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide90N-[3-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzyl]-acetamide912-(3-Aminomethyl-phenylamino)- 9-cyclopentyl-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one929-Cyclopentyl-2-(4-methoxy- benzylamino)-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one93N-Benzyl-4-(9-cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzenesulfonamide949-Cyclopentyl-5-methyl-2- [(thiophen-2-ylmethyl)-amino]- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one954-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- phenyl-benzamide964-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-methyl-benzenesulfonamide989-Cyclopentyl-2-(1H-indol-7- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one994-(9-Isopropyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)- 3-methoxy-N-(1-methyl-piperidin- 4-yl)-benzamide1004-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4- yl)-benzamide1014-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopentane]-2-ylamino)-3- methoxy-N-(1-methyl-piperidin- 4-yl)-benzamide1024-(9-Allyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide1033-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin- 4-yl)-benzenesulfonamide1044-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-methoxy- ethyl)-benzenesulfonamide1059-Cyclopentyl-5-methyl-2- [4-(4-methyl-piperazine-1- sulfonyl)-phenylamino]- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1069-Cyclopentyl-5-methyl-2- [(thiophen-3-ylmethyl)- amino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1079-Cyclopentyl-2-[(furan-3- ylmethyl)-amino]-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1083-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-methoxy- ethyl)-benzenesulfonamide1099-Cyclopentyl-5-methyl-2-[3- (pyrrolidine-1-sulfonyl)- phenylamino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one110N-Benzyl-3-(9-cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzenesulfonamide1114-(5,9-Dimethyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide1124-(5,9-Dimethyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-methyl-benzamide1134-(9-Isopropyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2- ylamino)-3-methoxy-N-methyl- benzamide1149-Cyclopropylmethyl-2-(2,2- dioxo-2,3-dihydro-1H- 2lambda*6*- benzo[c]thiophen-5-ylamino)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1162-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-methyl-9-(3- methyl-butyl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one117(9-Cyclopentyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclobutane]118(9-Cyclopentyl-2-(2,2-dioxo- 2,3-dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclopentane]1199-Allyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1202-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-ethyl-9-(1-ethyl- propyl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1219-tert-Butyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1229-tert-Butyl-2-(2,2-dioxo-2,3- dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)- 5-ethyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1232-(4-Chloro-phenylamino)-9-cyclopentyl- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1249-Cyclopentyl-2-[(furan-2- ylmethyl)-amino]-5-methyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1259-Cyclopentyl-5-methyl-2-(2- methyl-1H-indol-5-ylamino)- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1262-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-ethyl-5,7,8,9- tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1279-Cyclopentyl-2-[(2,3-dihydro- benzo[1,4]dioxin-6-ylmethyl)- amino]-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1289-Cyclopentyl-2-[(2,3-dihydro- benzo[1,4]dioxin-5-ylmethyl)- amino]-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1292-[(Benzo[b]thiophen-2- ylmethyl)-amino]-9-cyclopentyl- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1309-Cyclopentyl-2-(1H-indol-6- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1319-Cyclopentyl-5-methyl-2-(3-methyl- benzylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1329-Cyclopentyl-5-methyl-2-(4- [1,2,3]thiadiazol-4-yl- benzylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1332-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-9-(2-methoxy- phenyl)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1342-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-methyl-9-o-tolyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1359-(2-Chloro-phenyl)-2-(2,2- dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1362-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-9-(3-methoxy-phenyl)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1379-Cyclopentyl-5-methyl-2-m- tolylamino-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1389-Cyclopentyl-2-(3-methoxy- phenylamino)-5-methyl-5,7,8,9- tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1399-Cyclopentyl-2-(1H-indazol-5- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1403-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-N-(1-methyl- piperidin-4-yl)-benzamide1413-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-2,N-dimethyl-benzamide1423-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(2-hydroxy-ethyl)- 2-methyl-benzamide1433-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-4-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide1443-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-4-methoxy-N- methyl-benzamide1453-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-hydroxy- ethyl)-4-methoxy-benzamide1469-Cyclopentyl-5-methyl-2-[3- (piperazine-1-sulfonyl)- phenylamino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1474-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino-propyl)- 3-methoxy-N-methyl-benzamide1484-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(2-diethylamino- ethyl)-3-methoxy-benzamide1494-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino- propyl)-3-methoxy-benzamide1504-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-((1S,2R)-2-hydroxy- indan-1-yl)-3-methoxy-benzamide1514-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(4-hydroxy- butyl)-3-methoxy-benzamide1524-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-((R)-1- hydroxymethyl-2-methyl- propyl)-3-methoxy-benzamide1534-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1-hydroxymethyl- propyl)-3-methoxy-benzamide1544-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-hydroxy- propyl)-3-methoxy-benzamide1554-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1,1-dimethyl- 2-pyrrolidin-1-yl-ethyl)-3- methoxy-benzamide1564-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1,1-dimethyl- 2-piperidin-1-yl-ethyl)-3- methoxy-benzamide157N-(1-Benzyl-piperidin-4-yl)-4- (9-cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide1584-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-ylmethyl)-benzamide1594-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(3-hydroxy- propyl)-3-methoxy-benzamide1604-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- (4-methyl-piperazin-1-yl)-benzamide161N-(1-Aza-bicyclo[2.2.2]oct-3- yl)-4-(9-cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide1624-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1,2,2,6,6- pentamethyl-piperidin-4-yl)-benzamide1634-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- (1-methyl-piperidin-3-yl)-benzamide1644-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-hydroxy- butyl)-3-methoxy-benzamide1654-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(3- dimethylamino-2,2-dimethyl- propyl)-3-methoxy-benzamide1664-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(2-hydroxy- ethyl)-3-methoxy-benzamide1674-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N,N-bis-(2-hydroxy- ethyl)-3-methoxy-benzamide1684-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-[2-(2-hydroxy-ethoxy)- ethyl]-3-methoxy-benzamide1694-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3,N-dimethoxy-benzamide1703-[4-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-phenyl]-propionic acid171N-[4-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-phenyl]-acetamide172[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-phenyl]-acetic acid1739-Cyclopentyl-5-methyl-2-(2- oxo-2,3-dihydro-1H-indol-5- ylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1744-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methyl-benzoic acid1759-Cyclopentyl-2-[2-(1H-indol- 3-yl)-1-methyl-ethylamino]-5- methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one1764-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-cyclopropyl-benzamide1779-Cyclopentyl-2-[3-(1,1-dioxo- thiomorpholin-4-ylmethyl)- phenylamino]-5-methyl-5,7,8,9- tetrahydro-pyrimido[4,5-b][1,4]diazepin- 6-one178Cyclopropanecarboxylic acid [4- (9-cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-phenyl]-amide179Cyclopropanecarboxylic acid [4- (9-cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-phenyl]-amide1803-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-phenyl]-N-(1-methyl- piperidin-4-yl)-propionamide1812-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-phenyl]-N-(1-methyl- piperidin-4-yl)-acetamide1824-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclopropane]- 2-ylamino)-N-(2-diethylamino- ethyl)-3-methoxy-benzamide1834-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4] diazepin-3,1′-cyclopropane]-2- ylamino)-N-(3-methylamino-propyl)- 3-methoxy-benzamide1844-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- ((1S,2R)-2-hydroxy-indan-1-yl)-3- methoxy-benzamide1854-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- (4-hydroxy-butyl)-3-methoxy- benzamide186N-(1-Aza-bicyclo[2.2.2]oct-3- yl)-4-(9-cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-benzamide1874-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-3-yl)- benzamide1884-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- (2-hydroxy-ethyl)-3-methoxy-benzamide1894-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- [2-(2-hydroxy-ethoxy)-ethyl]-3- methoxy-benzamide1904-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)- 3,N-dimethoxy-benzamide191N-Acetyl-4-(9-cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzenesulfonamide1924-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-ethyl benzoic acid193N-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- yl)-benzamide194N-(1-Aza-bicyclo[2.2.2]oct-3- yl)-4-(9-cyclopentyl-5,7,7-trimethyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide1954-(9-Cyclopentyl-5,7,7-trimethyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(4- methyl-piperazin-1-yl)-benzamide1964-(9-Cyclopentyl-5,7,7-trimethyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-ylmethyl)-benzamide197N-(1-Benzyl-piperidin-4-yl)-4-(9- cyclopentyl-5,7,7-trimethyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide1984-(9-Cyclopentyl-5,7,7-trimethyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- (2-methoxy-ethyl)-benzamide1994-(9-Cyclopentyl-5,7,7-trimethyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N- pyridin-4-ylmethyl-benzamide2004-(9-Cyclopentyl-5,7,7-trimethyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-[2-(1H-imidazol- 4-yl)-ethyl]-3-methoxy-benzamide2014-(9-Cyclopentyl-5,7,7-trimethyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-furan-2-ylmethyl-3- methoxy-benzamide2024-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1-methyl- piperidin-2-ylmethyl)-benzamide2034-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(2-morpholin- 4-yl-ethyl)-benzamide204N-Cyclopentyl-4-(9-cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide2054-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- 1H-pyrrol-2-ylmethyl)-benzamide2064-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-piperidin- 4-yl-benzamide2074-(9-Cyclopropyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide2084-[9-(2-Hydroxy-ethyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide2094-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1-methanesulfonyl- piperidin-4-yl)-3-methoxy-benzamide210N-(1-Acetyl-piperidin-4-yl)-4- (9-cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-3-methoxy-benzamide211{4-[4-(9-Cyclopentyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoylamino]- piperidin-1-yl}-acetic acid ethyl ester212N-(1-Benzoyl-piperidin-4-yl)-4- (9-cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide2139-Cyclopentyl-2-[4-(4-methoxy-phenyl)- piperazin-1-yl]-5-methyl-5,7,8,9- tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2143-Chloro-4-(9-cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-N-(1-methyl-piperidin- 4-yl)-benzamide2154-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-fluoro-N-(1-methyl- piperidin-4-yl)-benzamide2164-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin- 4-yl)-3-trifluoromethoxy-benzamide2174-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-3- methoxy-N-(1-benzylpiperidin-4- yl)-benzamide218N-(1-Aza-bicyclo[2.2.2]oct-3-yl)- 4-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-3- methoxy-benzamide2194-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-N-(2- diethylamino-ethyl)-3-methoxy- benzamide2204-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-N-(2- dimethylamino-propyl)-3-methoxy- benzamide2214-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-N-(4- methyl-piperazin-1-yl)-3-methoxy- benzamide2224-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclobutane]-2-ylamino)-N- furan-2-ylmethyl-3-methoxy-benzamide2234-{9-[2-(2-Hydroxy- ethylcarbamoyl)-ethyl]-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino}-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide2243-Methoxy-4-[5-methyl-9-(2- methylcarbamoyl-ethyl)-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide2254-[9-(2-Dimethylcarbamoyl-ethyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide2264-{9-[2-(3-Dimethylamino- propylcarbamoyl)-ethyl]-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino}-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide2279-Cyclopentyl-2-(1H-indazol-5- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-6-one2284-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-hydroxy-N-(1- methyl-piperidin-4-yl)-benzamide2294-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3-ethyl- benzoic acid2304-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-benzoic acid2313-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(2-diethylamino- ethyl)-4-methoxy-benzamide2323-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino- propyl)-4-methoxy-benzamide2333-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-hydroxy-propyl)-4- methoxy-benzamide2343-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1,1-dimethyl-2- piperidin-1-yl-ethyl)-4-methoxy- benzamide2353-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-N-(1-methyl- piperidin-4-ylmethyl)-benzamide2363-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino-2,2- dimethyl-propyl)-4-methoxy- benzamide2374-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-ethyl-piperidin-4- yl)-3-methoxy-benzamide2384-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-cyclopropylmethyl- piperidin-4-yl)-3-methoxy- benzamide2394-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-benzoic acid2404-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(2-diethylamino- ethyl)-3-methoxy-benzamide241N-(1-Benzyl-piperidin-4-yl)-4-(9- cyclopropylmethyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide2424-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-ylmethyl)-benzamide243N-(1-Aza-bicyclo[2.2.2]oct-3-yl)- 4-(9-cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide2444-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1,2,2,6,6- pentamethyl-piperidin-4-yl)-benzamide2454-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-3-yl)-benzamide2464-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino-2,2- dimethyl-propyl)-3-methoxy-benzamide2474-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(3-dimethylamino- propyl)-3-methoxy-benzamide248N-Cyclopentyl-4-(9- cyclopropylmethyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide2494-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- 1H-pyrrol-2-ylmethyl)-benzamide2504-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-N-(1,1- dimethyl-2-pyrrolidin-1-yl-ethyl)- 3-methoxy-benzamide2514-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-N-(1,1- dimethyl-2-piperidin-1-yl-ethyl)-3- methoxy-benzamide2524-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-(1-benzylpiperidin-4- yl)-benzamide2534-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4- ylmethyl)-benzamide2544-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-N-(4-methyl-piperazin-1- yl)-benzamide2554-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-(1,2,2,6,6-pentamethyl- piperidin-4-yl)-benzamide2564-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-N-(3- dimethylamino-2,2-dimethyl- propyl)-3-methoxy-benzamide2574-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-pyridin-4-yl-benzamide2584-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-N-pyridin-4-ylmethyl- benzamide2594-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-N-(1-methyl-1H-pyrrol- 2-ylmethyl)-benzamide260N-Cyclopentyl-4-(9-Cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-benzamide2614-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- ethyl-N-(1-methyl-piperidin-4- yl)-benzamide2624-(9-Cyclopropylmethyl-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4- yl)-benzamide2633-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-[2-(2-hydroxy-ethoxy)- ethyl]-4-methoxy-benzamide2643-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4,N-dimethoxy-benzamide265N-(1-Benzyl-pyrrolidin-3-yl)-3-(9- cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-benzamide2663-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-N-(2- morpholin-4-yl-ethyl)-benzamide2673-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-[2-(1H-imidazol-4-yl)- ethyl]-4-methoxy-benzamide2683-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-N-(1-methyl- 1H-pyrrol-2-ylmethyl)-benzamide2693-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-N-(1-methyl- piperidin-2-ylmethyl)-benzamide2703-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-N-(2- methoxy-ethyl)-benzamide271N-(1-Benzyl-piperidin-4-yl)-3-(9- cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-4-methoxy-benzamide2723-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(4-hydroxy-butyl)-4- methoxy-benzamide2733-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-furan-2-ylmethyl-4- methoxy-benzamide2744-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- hydroxy-N-(1-methyl-piperidin-4- yl)-benzamide2754-(9-Cyclopropylmethyl-5,7,7-trimethyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoic acid2764-(9-Cyclopropylmethyl-5,7,7-trimethyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide2773-Methoxy-4-[9-(2-methoxy- phenyl)-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide2783-Methoxy-4-[9-(2-methoxy- phenyl)-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1,2,2,6,6-pentamethyl- piperidin-4-yl)-benzamide279N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3- methoxy-4-[9-(2-methoxy-phenyl)- 5-methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzamide2804-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3-methyl- benzoic acid2814-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-3,1′- cyclopropane-2-ylamino)-3- trifluoromethoxy-benzoic acid2822834-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- fluorobenzoic acid2844-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- trifluoromethoxy-N-(1-methyl- piperidin-4-yl)-benzamide285N-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-phenyl]-acetamide286N-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-trifluoromethyl- phenyl]-acetamide287N-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-phenyl]-2,2- dimethyl-propionamide288N-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-phenyl]- methanesulfonimide2899-Cyclopentyl-2-(1,1-dioxo-1H- 1lambda*6*-benzo[b]thiophen-5- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2902-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen- 5-ylamino)-5-methyl-9-p-tolyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one291Cyclopropanecarboxylic acid [2- methyl-4-(5-methyl-6-oxo-9-p- tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-phenyl]-amide2925-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzo[b]thiophene-2- carboxylic acid2939-Cyclopentyl-5-methyl-2-[4- (morpholine-4-carbonyl)- phenylamino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2949-Cyclopentyl-5-methyl-2-(3- oxo-3,4-dihydro-2H- benzo[1,4]oxazin-7-ylamino)- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2959-Cyclopentyl-5-methyl-2-(3-oxo- 3,4-dihydro-2H-benzo[1,4]oxazin- 6-ylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2965-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzo[b]thiophene-2- carboxylic acid2979-Cyclopentyl-5-methyl-2-[4- (morpholine-4-carbonyl)- phenylamino]-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2989-Cyclopentyl-5-methyl-2-(3-oxo- 3,4-dihydro-2H-benzo[1,4]oxazin- 7-ylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one2999-Cyclopentyl-5-methyl-2-(3-oxo- 3,4-dihydro-2H-benzo[1,4]oxazin- 6-ylamino)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3004-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N,N-dimethyl- benzenesulfonamide3014-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methyl-N-(1-methyl-piperidin-4- yl)-benzamide3024-(9-Isobutyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-4-yl)-benzamide3034-(9-Isobutyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl- piperidin-3-yl)-benzamide304N-(1-Benzyl-piperidin-4-yl)-4-(9- isobutyl-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide305N-(1-Aza-bicyclo[2.2.2]oct-3-yl)- 4-(9-isobutyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide3064-(9-Isobutyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1,2,2,6,6- pentamethyl-piperidin-4-yl)-benzamide307N-(2-Diethylamino-ethyl)-4-(9-isobutyl- 5-methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzamide3083-Methoxy-4-(5-methyl-6-oxo-9- o-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin- 4-yl)-benzamide3093-Methoxy-4-(5-methyl-6-oxo-9- o-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin- 3-yl)-benzamide310N-(1-Benzyl-piperidin-4-yl)-3- methoxy-4-(5-methyl-6-oxo-9- o-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-benzamide311N-(1-Aza-bicyclo[2.2.2]oct-3-yl)- 3-methoxy-4-(5-methyl-6-oxo-9- o-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzamide3123-Methoxy-4-(5-methyl-6-oxo-9- o-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1,2,2,6,6-pentamethyl- piperidin-4-yl)-benzamide313N-(2-Diethylamino-ethyl)-3- methoxy-4-(5-methyl-6-oxo-9-o- tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzamide3143-Methoxy-4-[9-(4-methoxy- phenyl)-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide3153-Methoxy-4-[9-(4-methoxy-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-N-(1-methyl-piperidin- 3-yl)-benzamide316N-(1-Benzyl-piperidin-4-yl)-3-methoxy- 4-[9-(4-methoxy-phenyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-benzamide317N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3- methoxy-4-[9-(4-methoxy-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzamide3183-Methoxy-4-[9-(4-methoxy-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-N-(1,2,2,6,6-pentamethyl- piperidin-4-yl)-benzamide319N-(2-Diethylamino-ethyl)-3-methoxy-4- [9-(4-methoxy-phenyl)-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin- 2-ylamino]-benzamide3204-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- (1-ethyl-pyrrolidin-3-yl)-3- methoxy-N-benzamide3214-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N- [2-(4-iso322N-(1-Benzyl-pyrrolidin-3-yl)-4-(9- cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-benzamide3234-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3-fluoro- N-(1-methyl-piperidin-4-yl)-benzamide324N-[2-Chloro-4-(9-cyclopentyl-5- methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin- 2-ylamino)-phenyl]-acetamide3254-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1,1-dioxo-tetrahydro- 1lambda*6*-thiophen-3-yl)- benzenesulfonamide326327Cyclopropanecarboxylic acid {4- [9-(4-methoxy-phenyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-2-methyl-phenyl}-amide328Cyclopropanecarboxylic acid [4-(5-ethyl- 6-oxo-9-p-tolyl-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-2-methyl-phenyl]-amide329Cyclopropanecarboxylic acid {4- [9-(2,6-difluoro-phenyl)-5-methyl- 6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-2-methyl-phenyl}-amide330Cyclopropanecarboxylic acid {4- [5-ethyl-9-(4-methoxy-phenyl)-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-2-methyl-phenyl}-amide3312-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-ethyl-9-p-tolyl- 5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3322-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-9-(4-methoxy-phenyl)- 5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3332-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-ethyl-9-(4-methoxy- phenyl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3349-(4-tert-Butyl-phenyl)-2-(2,2- dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3359-(4-tert-Butyl-phenyl)-2-(2,2- dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-ethyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3362-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-methyl-9-(4-morpholin- 4-yl-phenyl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one337Cyclopropanecarboxylic acid {2- methyl-4-[5-methyl-9-(4-morpholin-4- yl-phenyl)-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino]-phenyl}-amide3382-(2,2-Dioxo-2,3-dihydro-1H- 2lambda*6*-benzo[c]thiophen-5- ylamino)-5-ethyl-9-(4-morpholin-4- yl-phenyl)-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3399-(2,6-Difluoro-phenyl)-2-(2,2-dioxo- 2,3-dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)-5- methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3409-(2,6-Difluoro-phenyl)-2-(2,2-dioxo- 2,3-dihydro-1H-2lambda*6*- benzo[c]thiophen-5-ylamino)-5- ethyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one3414-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4- yl)-benzamide mesylate342Cyclopropanecarboxylic acid {4- [9-(4-tert-butyl-phenyl)-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-2-methyl-phenyl}-amide343{4-[4-(9-Cyclopentyl-5-methyl-6- oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoylamino]- piperidin-1-yl}-acetic acid3444-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-isopropyl-piperidin- 4-yl)-3-methoxy-benzamide3454-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-[1- (tetrahydro-pyran-4-yl)-piperidin-4- yl]-benzamide3464-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-benzoylamino}-piperidine- 1-carboxylic acid tert-butyl ester347N-(R)-(1-Aza-bicyclo[2.2.2]oct-3- yl)-4-(9-cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-benzamide348N-(S)-(1-Aza-bicyclo[2.2.2]oct-3-yl)- 4-(9-cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-3- methoxy-benzamide3494-(9-Cyclopentyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H- spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N-(1- methyl-piperidin-4-yl)-benzamide350N-Acetyl-4-[9-(4-methoxy-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzenesulfonamide351N-Acetyl-4-[9-(2,6-difluoro-phenyl)-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzenesulfonamide352N-Acetyl-4-[5-methyl-9-(4-morpholin- 4-yl-phenyl)-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino]-benzenesulfonamide.1***4-(9-Cyclopentyl-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoic acid 2***4-(9-Cyclopentyl-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)- benzamide 3*4-(9-Cyclopentyl-8-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoic acid 4*4-(9-Cyclopentyl-5,8-dimethyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoic acid5*4-(9-Cyclopentyl-8-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-benzoic acid64-(9-Cyclopentyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-benzoic acid7***4-(9-Cyclopentyl-8-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzoic acid8*****4-(9-Cyclopentyl-5,8-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzoic acid9*4-(9-Cyclopentyl-6-oxo-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-benzoic acid10*9-Cyclohexyl-2-(4-hydroxy-phenylamino)-5,7,8,9- tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one 11*9-Cyclopentyl-2-(4-hydroxy-phenylamino)-7- methyl-5,7,8,9-tetrahydro-pyrimido[4,5- b][1,4]diazepin-6-one129-Cyclopentyl-2-(4-hydroxy-phenylamino)-8- isopropyl-5-methyl-5,7,8,9-tetrahydro- pyrimido[4,5-b][1,4]diazepin-6-one 13*9-Cyclopentyl-2-(4-hydroxy-phenylamino)-5,8- dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5- b][1,4]diazepin-6-one 14*4-(9-Benzyl-5-methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-benzoic acid 15***4-(5-Methyl-6-oxo-9-phenyl-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)- benzoic acid164-(9-Cyclopentyl-5,7,7-trimethyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-benzoic acid17*4-(9-Cyclopentyl-7-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)- benzamide18**4-(9-Cyclopentyl-7-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin-4-yl)-benzamide19*4-(9-Cyclopentyl-8-isopropyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl-piperidin-4- yl)-benzamide20***4-(9-Cyclopentyl-5,7-dimethyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl-piperidin-4- yl)-benzamide214-[9-(1-Ethyl-propyl)-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4-yl)-benzamide224-[9-(1-Ethyl-propyl)-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino]-N-(1- methyl-piperidin-4-yl)-benzamide 23*4-(9-Cyclopentyl-8-isopropyl-5-methyl-6-oxo- 6,7,8,9-tetrahydro-5H-pyrimido[4,5- b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1- methyl-piperidin-4-yl)-benzamide 24*4-[9-(1-Ethyl-propyl)-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino]-3-methoxy-N-(1-methyl-piperidin-4-yl)- benzamide 253-Methoxy-N-(1-methyl-piperidin-4-yl)-4-[6-oxo-9- (tetrahydro-pyran-4-yl)-6,7,8,9-tetrahydro-5H- pyrimido[4,5-b][1,4]diazepin-2-ylamino]- benzamide 26**3-Methoxy-4-[5-methyl-6-oxo-9-(tetrahydro- pyran-4-yl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5- b][1,4]diazepin-2-ylamino]-N-(1-methyl-piperidin- 4-yl)-benzamide 274-[5-Ethyl-9-(1-ethyl-propyl)-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino]-3-methoxy-N-(1-methyl-piperidin-4-yl)- benzamide 28**4-(9-Cyclopentyl-5-ethyl-7-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)- benzamide29—*4-(9-Benzyl-5-methyl-6-oxo-6,7,8,9-tetrahydro- 5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-N-(1-methyl-piperidin-4-yl)-benzamide 30**3-Methoxy-4-(5-methyl-6-oxo-9-phenyl-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2- ylamino)-N-(1-methyl-piperidin-4-yl)-benzamide31***4-(9-Cyclopentyl-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-spiro[pyrimido[4,5-b][1,4]diazepin- 3,1′-cyclopropane]-2-ylamino)-N-(1-methyl- piperidin-4-yl)-benzamideand pharmaceutically acceptable salts and esters thereof. |
