ANTIBODIES TO MICROBIOME, STRESS FACTORS AND MAST CELL MARKERS AS DIAGNOSTIC MARKERS FOR IBS

摘要

The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether a sample from an individual is an IBS sample or a healthy control sample using a statistical algorithm. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions.

主权项

1. A method for aiding in the diagnosis of irritable bowel syndrome (IBS) in a subject, said method comprising:
measuring the level of an array of bacterial antigen antibody markers in a biological sample taken from the subject; applying a statistical analysis to the measured level of the array of bacterial antigen antibody markers to generate a bacterial antigen antibody marker profile; and comparing said bacterial antigen antibody marker profile to a diagnostic model to determine whether the individual has an increased likelihood of having IBS compared to being a healthy control.