DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS AND METHOD OF MANUFACTURE THEREOF

摘要

The drug eluting device consists of an implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution.

主权项

1. A method of making a drug-eluting medical device, comprising the steps of:
a) Vacuum depositing a first layer of a biocompatible material onto a substrate; b) Vacuum deposing a sacrificial layer of material onto the first layer of a biocompatible material; c) Removing portions of the sacrificial layer to form internal chamber defining regions of the sacrificial layer; d) Vacuum depositing a second layer of biocompatible material onto the internal chamber defining regions of the sacrificial layer and the first layer of biocompatible material; e) Forming at least one of a plurality of openings passing through the second layer of biocompatible and communicating with the internal chamber defining regions of the sacrificial layer; f) Removing the internal chamber defining regions of the sacrificial layer thereby forming at least one of a plurality of internal chambers residing entirely between the first layer of biocompatible material and the second layer of biocompatible material; and g) Disposing at least one of a plurality of cover members covering the at least one of a plurality of openings, the at least one of a plurality of cover members having a first position which covers at least one of the plurality of openings and a second position which uncovers at least one of the plurality of openings.