发明名称 |
Compositions and Methods for Treatment of Mitochondrial Diseases and for Differentiation of Cells to Neurons |
摘要 |
Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a Pumilio-like protein and/or an inhibitor of a serine/arginine-rich family of pre-mRNA splicing factor (SR) protein to a subject. Also provided are methods, compositions, systems and kits for transdifferentiating target cells to neurons, which find use in producing neurons for the development of new therapies, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example, for use in treating human disorders of the CNS. |
申请公布号 |
US2015344878(A1) |
申请公布日期 |
2015.12.03 |
申请号 |
US201314654998 |
申请日期 |
2013.12.20 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Lu Bingwei;Gehrke Stephan |
分类号 |
C12N15/113;A61K45/06;C12N5/0793;A61K31/7105 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating mitochondrial disease in a subject having a mitochondrial disease, comprising:
administering a therapeutically effective amount of an inhibitor of a Pumilio-like protein and/or an inhibitor of an SR protein to the subject. |
地址 |
Palo Alto CA US |