| 主权项 |
1. A method for treating or preventing breast cancer occurrence or recurrence in a patient in need thereof, comprising administering to the patient in need thereof an effective amount of a compound of formula I:wherein:
R1 is H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl, —OH, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl or —O(C2-C12)alkynyl of R1 is optionally substituted with one or more Z1a groups and wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of R1 is optionally substituted with one or more Z1b groups; R2 is H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl, —OH, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl of R2 is optionally substituted with one or more Z2a groups and wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of R1 is optionally substituted with one or more Z2b groups; R3 is H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl, —OH, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl or —O(C2-C12)alkynyl of R3 is optionally substituted with one or more Z3a groups and wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of R3 is optionally substituted with one or more Z3b groups; R4 is H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl, —OH, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —O(C1-C12)alkyl, —O(C2-C12)alkenyl, —O(C2-C12)alkynyl of R4 is optionally substituted with one or more Z4a groups and wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of R4 is optionally substituted with one or more Z4b groups; Z1a is —OH, halogen, —O(C1-C6)alkyl, —C(═O)O(C1-C6)alkyl, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of Z1a is optionally substituted with one or more groups selected from (C1-C6)alkyl, —OH, halogen and —O(C1-C6)alkyl; Z1b is (C1-C6)alkyl, —OH, halogen or —O(C1-C6)alkyl; Z2a is —OH, halogen, —O(C1-C6)alkyl, —C(═O)O(C1-C6)alkyl, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of Z2a is optionally substituted with one or more groups selected from (C1-C6)alkyl, —OH, halogen and —O(C1-C6)alkyl; Z2b is (C1-C6)alkyl, —OH, halogen or —O(C1-C6)alkyl; Z3a is —OH, halogen, —O(C1-C6)alkyl, —C(═O)O(C1-C6)alkyl, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of Z3a is optionally substituted with one or more groups selected from (C1-C6)alkyl, —OH, halogen and —O(C1-C6)alkyl; Z3b is (C1-C6)alkyl, —OH, halogen or —O(C1-C6)alkyl; Z4a is —OH, halogen, —O(C1-C6)alkyl, —C(═O)O(C1-C6)alkyl, (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl, wherein any (C3-C8)carbocycle, 5-10 membered heteroaryl or aryl of Z4a is optionally substituted with one or more groups selected from (C1-C6)alkyl, —OH, halogen and —O(C1-C6)alkyl; and Z4b is (C1-C6)alkyl, —OH, halogen or —O(C1-C6)alkyl; or a pharmaceutically acceptable salt thereof. |
