HIGHLY PERMEATING TERBINAFINE FORMULATION

摘要

The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomycosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.

主权项

1. A topical hydroalcoholic formulation for the treatment of onychomycosis, wherein the formulation comprises:
terbinafine or a salt thereof; a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, wherein the acid is selected from the group consisting of a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof; a lower alcohol; and water.