| 发明名称 |
FILOVIRUS FUSION PROTEINS AND THEIR USES |
| 摘要 |
This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections. |
| 申请公布号 |
US2015346215(A1) |
申请公布日期 |
2015.12.03 |
| 申请号 |
US201514704792 |
申请日期 |
2015.05.05 |
| 申请人 |
The United States of America as Represented by the Secretary of the Department of Health and Human ;U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND |
发明人 |
Kaplan Gerardo;Konduru Krishnamurthy;Jacques Jerome;Bavari Sina;Bradfute Steven |
| 分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of detecting neutralizing antibodies in a biological sample from a patient, the method comprising contacting the biological sample with a cell susceptible to Filovirus infection and a recombinant Vesicular Stomatitis Virus (VSV) expressing a Filovirus GP. |
| 地址 |
Rockville MD US |
