Computer-Implemented System And Method For Improving Glucose Management Through Cloud-Based Modeling Of Circadian Profiles

摘要

A computer-implemented system and method for improving glucose management through cloud-based modeling of circadian profiles is provided. For each daily meal peeriod, two sets of pre- and post-meal period data that include a blood glucose level and a diabetes medication dosing are stored into a circadian profile for a diabetic patient in a cloud computing infrastructure. Predicted blood glucose is modeled over the infrastructure and the access will be validated. A model, including expected blood glucose values and their predicted errors is created from the blood glucose levels in each profile and visualized in a log-normal distribution. Target ranges for blood glucose are determined and superimposed over the expected values. Pharmacodynamics of the medication are obtained. An incremental change in dosing of the medication is propagated over a model day and the expected blood glucose values and their predicted errors are adjusted in response to the incremental dosing change.

主权项

1. A computer-implemented method for improving glucose Management through cloud-based modeling of circadian profiles, comprising the steps of:
storing online, for each of a plurality of daily meal periods occurring over a recent observational time frame, at least two sets of pre- and post-meal period data that comprise a blood glucose level and a diabetes medication dosing into a circadian profile for a diabetic patient in a cloud computing infrastructure; and modeling predicted blood glucose for the patient over the cloud computing infrastructure, comprising:
validating access to the circadian profile;creating a model comprising expected blood glucose values and their predicted errors at each daily meal period from the blood glucose levels in each record in the validated circadian profile;visualizing the model of the expected blood glucose values and their predicted errors in a log-normal distribution;determining target ranges for blood glucose at each meal period and superimposing the target ranges over the expected blood glucose values; andobtaining pharmacodynamics of the diabetes medication; andpropagating an incremental change in dosing of the identified diabetes medication over the model day and adjusting the expected blood glucose values and their predicted errors in response to the suggested incremental dosing change, wherein the steps are performed on a suitably-programmed computer.