发明名称 |
REDUCTION OF TGF BETA SIGNALING IN MYELOID CELLS IN THE TREATMENT OF CANCER |
摘要 |
Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGFβ signaling, for example, by reducing TGFβ receptor II expression in myeloid cells. Vectors comprising a TGFβ receptor II RNAi nucleic acid sequence operably linked to a myeloid specific promoter also are provided. A method of diagnosing cancer in an individual by determining TGFβ receptor II expression in myeloid cells in the individual is provided. Additionally, a method of modulating TGFβ activity in myeloid cells in a cancer patient comprising administering a regulator of at least one of the GSK3 and PI3K pathways to the patient is provided. |
申请公布号 |
US2015344891(A1) |
申请公布日期 |
2015.12.03 |
申请号 |
US201514820697 |
申请日期 |
2015.08.07 |
申请人 |
The United States of America, as represented by the Secretary, Department of Health and Human |
发明人 |
Yang Li |
分类号 |
C12N15/113;G01N33/574;C12Q1/68;A61K31/5377 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Bethesda MD US |