HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS

摘要

The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

主权项

1. A multiwell plate for non-template directed synthesis of nucleic acid molecules, the plate comprising:
(a) a magnetic bead located in each of a plurality of wells of the plate, and (b) an electrochemically generated acid being present in one or more well, wherein the bead is between 1.0 μm and 100 μm in diameter.