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1. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein; W is N or O, wherein N is substituted with hydrogen, C1-C6 alkyl, or C3-C5 cycloalkyl; Y is a group —S(O)p— wherein p is 0, 1 or 2; a group —O(CR3R4)n—; a group —(CR5R6)n—; a group —NR7—; a group —OC(O)—; a group —OC(O)NH—; or a group —OC(O)O—; R3, R4, R5, and R6 are each independently hydrogen, fluorine, or C1-C6 alkyl, or, respectively, R3 and R4, or R5 and R6 form, together with the carbon atom to which they are attached, a saturated 3-6 membered carbocyclic monocyclic ring optionally substituted by a group C1-C6 alkyl, hydroxyl, or halo; n is 0, 1, 2, or 3; R7 is hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl wherein said C1-C6 alkyl or C3-C7 cycloalkyl are optionally substituted by a C1-C3 alkyl group, C3-C6 cycloalkyl group, hydroxyl, cyano, or halo; R1 is a group represented by formula (IIa), (IIb), or (IIc): R8 and R9 are each independently hydrogen or C1-C6 alkyl, or R8 and R9 may form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated monocyclic or a fused or Spiro bicyclic ring system optionally containing a further heteroatom which is oxygen or nitrogen, said nitrogen atom being optionally substituted by C1-C6 alkyl; wherein said C1-C6 alkyl groups may be optionally substituted by a C1-C6 alkyl group, C3-C6 cycloalkyl group, hydroxyl, or halo; X1, X2, X3, X4, and X5 are each independently a carbon atom, a nitrogen atom, a group —(CH)— or a group —NH—; such that each combination thereof forms an aromatic ring system; R10 is hydrogen, —CN, —NRARB, —N(RC)(C2-C6alkylene)-NRARB, —N(RC)(C3-C7cycloalkylene)_NRARB, —(C1-C6alkylene)-NRARB, —(C3-C7cycloalkylene)-NRARB, —O—(C2-C6alkylene)-NRARB, —O—(C3-C7cycloalkylene)-NRARB, —S—(C2-C6alkylene)-NRARB, —S—(C3-C7cycloalkylene)-NRARB, —N(RC)C(O)—(C1-C6alkylene)-NRARB, —N(RC)C(O)—(C3-C7cycloalkylene)-NRARB, —C(O)N(RC)—(C2-C6alkylene)-NRARB, —C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, C(O)N(RC)—(C2-C6alkylene)-ORD, —C(O)N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)C(O)NRARB, C(O)NRARB, —N(RC)C(O)N(RC)—(C2-C6alkylene)-NRARB, —N(RC)C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, —(C2-C6alkylene)-ORD, —(C3-C7cycloalkylene)-ORD, —O—(C2-C6alkylene)-ORD, —O—(C3-C7cycloalkylene)-ORD, —S—(C2-C6alkylene)-ORD, —S—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C1-C6alkylene)-NRARB, —N(RC)S(O)2—(C3-C7cycloalkylene)-NRARB, —S(O)2NRC)—(C2-C6alkylene)-NRARB, —S(O)2N(RC)—(C3-C7cycloalkylene)-NRARB, —S(O)2N(RC)—(C2-C6alkylene)-ORD, —S(O)2N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C2-C6alkylene)-ORD, —N(RC)S(O)2—(C3-C7cycloalkylene)-ORD, —S(O)2N(RARB), —N(RC)2(O)2RD, —N(RC)C(O)RC, —ORC, —SRC, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl), (C5-C7heterocycloalkyl)(C3-C6cycloalkyl)-, or C3-C7 heterocycloalkylcarbonyl; wherein any of the C1-C6alkyl, C3-C6cycloalkyl, —(C1-C6alkylene)- —(C2-C6alkylene)-, —(C3-C7cycloalkylene)-, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl), (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl) and (C3-C7heterocycloalkyl)carbonyl portion in the above listed groups may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, hydroxyl, or halo; R11 is linked to X4 and is hydrogen; —CN; C1-C6 alkyl which is substituted by —CN, —ORC, —SRC, or halo; C3-C6cycloalkyl which is substituted by C1-C4 alkyl, —CN, —ORC, —SRD, or halo; —NRARB, —N(RC)(C2-C6alkylene)-NRARB, —N(RC)(C3-C7cycloalkylene)-NRARB, —(C1-C6alkylene)-NRARB, —(C3-C7cycloalkylene)-NRARB, —O—(C2-C6alkylene)-NRARB, —O—(C3-C7cycloalkylene)-NRARB, —S—(C2-C6alkylene)-NRARB, —S—(C3-C7cycloalkylene)-NRARB, —N(RC)C(O)—(C1-C6alkylene)-NRARB, —N(RC)C(O)—(C3-C7cycloalkylene)-NRARB, —C(O)N(RC)—(C2-C6alkylene)-NRARB, —C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, —C(O)N(RC)—(C2-C6alkylene)-ORD, —C(O)N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)C(O)N(RARB), —C(O)N(RARB), —N(RC)C(O)N(RC)—(C2-C6alkylene)-NRARB, —N(RC)C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, —O—(C2-C6alkylene)-ORD, —O—(C3-C7cycloalkylene)-ORD, —S—(C2-C6alkylene)-ORD, —S—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C1-C6alkylene)-NRARB, —N(RC)S(O)2—(C3-C7cycloalkylene)-NRARB, —S(O)2N(RC)—(C2-C6alkylene)-NRARB, —S(O)2N(RC)—(C3-C7cycloalkylene)-NRARB, —S(O)2N(RC)—(C2-C6alkylene)-ORD, —S(O)2N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C2-C6alkylene)-ORD, —N(RC)S(O)2, (C3-C7cycloalkylene)-ORD, —S(O)2N(RARB), —N(RC)S(O)2RD, —N(RC)C(O)RC, ORC, SRC, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl), (C5-C7heterocycloalkyl)(C3-C6cycloalkyl) or (C3-C7 heterocycloalkyl)carbonyl, wherein any of such C1-C6alkyl, C3-C6cycloalkyl, —(C1-C6alkylene)-, —(C2-C6alkylene)-, —(C3-C7cycloalkylene)-, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl), (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl) and (C3-C7heterocycloalkyl)carbonyl portion in the above listed groups may be optionally substituted by one, two or three groups R25 which are independently selected from the group consisting of C1-C6 alkyl, (C1-C3) haloalkyl, (C1-C4)hydroxyalkyl, C3-C7 cycloalkyl, hydroxyl, and halo; or R11 is linked to X4 and is phenyl or 5- or 6-membered monocyclic heteroaryl, wherein such phenyl or 5- or 6-membered monocyclic heteroaryl is substituted by a group selected from the group consisting of C1-C6 alkyl which is substituted by a group —CN; C3-C6 cycloalkyl which is substituted by —CN, —ORC, —SRC or halo; —N(RC)(C2-C6alkylene)-NRARB, —N(RC)(C3-C7cycloalkylene)-NRARB, —(C1-C6alkylene)-NRARB, —(C3-C7cycloalkylene)-NRARB, —O—(C3-C7cycloalkylene)-NRARB, —S—(C2-C6alkylene)-NRARB, —S—(C3-C7cycloalkylene)-NRARB, —N(RC)C(O)—(C1-C6alkylene)-NRARB, —N(RC)C(O)—(C3-C7cycloalkylene)-NRARB, —C(O)N(RC)—(C2-C6alkylene)-NRARB, —C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, —C(O)N(RC)—(C2-C6alkylene)-ORD, —C(O)N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)C(O)N(RC)—(C2-C6alkylene)-NRARB, —N(RC)C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, —O—(C3-C7cycloalkylene)-ORD, —S—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C1-C6alkylene)-NRARB, —N(RC)S(O)2—(C3-C7cycloalkylene)-NRARB, —S(O)2N(RC)—(C2-C6alkylene)-NRARB, —S(O)2N(RC)—(C3-C7cycloalkylene)-NRARB, —S(O)2N(RC)—(C2-C6alkylene)-ORD, —S(O)2N(RC)—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2—(C2-C6alkylene)-ORD, —N(RC)S(O)2—(C3-C7cycloalkylene)-ORD, —N(RC)S(O)2RD, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl), (C5-C7heterocycloalkyl)(C3-C6cycloalkyl) and (C3-C7heterocycloalkyl)carbonyl, wherein any of such C1-C6alkyl, C3-C6cycloalkyl, —(C1-C6alkylene)-, —(C2-C6alkylene)-, —(C3-C7cycloalkylene)-, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl), (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl) and (C3-C7heterocycloalkyl)carbonyl portion in the above listed groups may be optionally substituted by one, two, or three groups R25 which are independently selected in the group consisting of C1-C6alkyl, (C1-C3) haloalkyl, (C1-C4)hydroxyalkyl, C3-C7cycloalkyl, hydroxyl, and halo; RA and RB are at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl, such C1-C6 alkyl and C3-C7cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORD, —CN or halo; alternatively, RA and RB, form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated heterocyclic monocyclic or bicyclic ring system which is optionally substituted by one or more of —ORD, —CN, halo, C1-C6 alkyl or C3-C7cycloalkyl, such C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORD, —CN or halo; and which 5-11-membered saturated heterocyclic monocyclic or bicyclic ring optionally contains a further heteroatom which is oxygen or nitrogen, said nitrogen atom optionally substituted by C1-C6 alkyl or C3-C6 cycloalkyl, wherein any of said C1-C6 alkyl or C3-C6cycloalkyl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORD, —CN, or halo; or RA and RB may be linked to one carbon atom of the —(C1-C6alkylene)-, —(C2-C6alkylene)- or —(C3-C7cycloalkylene)-portion of the group linked to the nitrogen to which they are connected to form a saturated cycle of up to 6 ring atoms; RC is at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl and C3-C6 cycloalkyl being optionally substituted by a C1-C3 alkyl group, —ORD, —CN, or halo; RD is at each occurrence independently hydrogen, —CH3, or —C2H5; R12 and R13 are independently hydrogen, C1-C6 alkyl, or halogen; A is a divalent cycloalkylene radical having 5, 6, or 7 ring atoms; said cycloalkylene ring being attached to W and Y, and fused to a phenyl ring or to a monocyclic heteroaryl ring having 5 or 6 ring atoms, said phenyl or heteroaryl ring being optionally substituted by one or two groups R24; R24 is at each occurrence independently C1-C6 alkyl, halogen, or cyano; R2 is a group of formula (IIIa), (IIIb), (IIIc), or (IIId): wherein R14 is —F, —CH3, —C2H5, —CH2OH, —CH2OMe, —CF2CF3, —CH2SCH3, —SCH3 or —SC2H5; R15 and R16 are independently —CH3 or —C2H5; R17 is lone electron pair, hydrogen, —CF3, —NRERF, —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), aryl, or heteroaryl wherein any of such —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), aryl, or heteroaryl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, or halo; or R17 is a group of formula (IV) wherein R20 is —F, —CH3, —C2H5, —CH2OH, —CH2OMe, —CF2CF3, —CH2SCH3, —SCH3 or —SC2H5; R21 is —CH3 or —C2H5; or R20 and R21 form, together with the carbon atom to which they are attached, a saturated 3-7-membered monocyclic ring; RE and RF are each independently C1-C6 alkyl, optionally substituted by a C1-C3 alkyl group, —ORG, —CN, or halo; alternatively, RE and RF form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated monocyclic or bicyclic heterocyclic ring system which is optionally substituted by one or more of —ORG, —CN, halo, C1-C6 alkyl or C3-C7 cycloalkyl, said C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a group C1-C3 alkyl, C3-C7cycloalkyl, —ORG, —CN or halo; and which 5-11-membered saturated monocyclic or bicyclic heterocyclic ring optionally contains a further heteroatom which is oxygen or nitrogen, said nitrogen atom optionally substituted by C1-C6 alkyl or C3-C6 cycloalkyl, wherein any of said C1-C6 alkyl or C3-C6 cycloalkyl may be optionally substituted by a C1-C6 alkyl group or C3-C7 cycloalkyl group; RG is hydrogen, —CH3, or —C2H5; R18 is lone electron pair, hydrogen, aryl, heteroaryl, —(C1-C6alkyl), —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) or (C5-C7heterocycloalkyl)-(C3-C6 cycloalkyl), wherein any of such aryl, heteroaryl, —(C1-C6alkyl), —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) and (C5-C7heterocycloalkyl)-(C3-C6 cycloalkyl) may be optionally substituted by —CN, —OH, halo, —COORM, C1-C6alkyl, C3-C6cycloalkyl, —O—(C1-C6alkyl), —O—(C3-C6cycloalkyl), —S—(C1-C6alkyl), —S—(C3-C6cycloalkyl), —NRHRJ, —N(RL)(C2-C6alkylene)-NRHRJ, —N(RL)(C3-C7cycloalkylene)-NRHRJ, —(C1-C6alkylene)-NRHRJ, —(C3-C7cycloalkylene)-NRHRJ, —O—(C2-C6alkylene)-NRHRJ, —O—(C3-C7cycloalkylene)-NRHRJ, —S—(C2-C6alkylene)-NRHRJ, —S—(C3-C7cycloalkylene)-NRHRJ, —N(RL)C(O)—(C1-C6alkylene)-NRHRJ, —N(RL)C(O)—(C3-C7cycloalkylene)-NRHRJ, —C(O)N(RL)—(C2-C6alkylene)-NRHRJ, —C(O)N(RL)—(C3-C7cycloalkylene)-NRHRJ, —C(O)N(RL)—(C2-C6alkylene)-ORM, —C(O)N(RL)—(C3-C7cycloalkylene)-ORM, —N(RL)C(O)N(RHRJ), —C(O)N(RHRJ), —N(RL)C(O)N(RL)—(C2-C6alkylene)-NRHRJ, —N(RL)C(O)N(RL)—(C3-C7cycloalkylene)-NRHRJ, —O—(C2-C6alkylene)-ORM, —O—(C3-C7cycloalkylene)-ORM, —S—(C2-C6alkylene)-ORM, —S—(C3-C7cycloalkylene)-ORM, —N(RL) S(O)2—(C1-C6alkylene)-NRHRJ, —N(RL)S(O)2—(C3-C7cycloalkylene)-NRHRJ, —S(O)2N(RL)—(C2-C6alkylene)-NRHRJ, —S(O)2N(RL)—(C3-C7cycloalkylene)-NRHRJ, —S(O)2N(RL)—(C2-C6alkylene)-ORM, —S(O)2N(RL)—(C3-C7cycloalkylene)-ORM, —N(RL)S(O)2—(C2-C6alkylene)-ORM, —N(RL)S(O)2—(C3-C7cycloalkylene)-ORM, —S(O)2N(RHRJ), —N(RL)S(O)2RL, —N(RL)C(O)RL, ORL, SRL, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6 alkyl) or (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl), wherein any of such C1-C6alkyl, C3-C6cycloalkyl, —(C1-C6alkylene)- —(C2-C6alkylene)-, —(C3-C7cycloalkylene)-, —(C3-C7heterocycloalkyl), (C5-C7heterocycloalkyl)-(C1-C6alkyl) and (C5-C7 heterocycloalkyl)-(C3-C6 cycloalkyl) portion in the above listed groups may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORL or halo; RH and RJ, are at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6alkyl or C3-C6cycloalkyl being optionally substituted by a C1-C3 alkyl group, —ORM, CN, or halo; alternatively, RH and RJ form, together with the nitrogen atom to which they are attached, a 5-11-membered saturated monocyclic or bicyclic heterocyclic ring system which is optionally substituted by one or more of —ORM, —CN, halo, C1-C6 alkyl, or C3-C7 cycloalkyl, said C1-C6 alkyl and C3-C7 cycloalkyl being optionally substituted by a C1-C3 alkyl group, C3-C7cycloalkyl group, —ORM, CN or halo; and which 5-11-membered saturated monocyclic or bicyclic heterocyclic ring optionally contains a further heteroatom which is oxygen or nitrogen, said nitrogen atom optionally substituted by C1-C6 alkyl or C3-C6 cycloalkyl, wherein any of said C1-C6 alkyl or C3-C6 cycloalkyl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, —ORM, CN, or halo; and/or RH and RJ may be linked to one carbon atom of the —(C1-C6alkylene)-, —(C2-C6alkylene)- or —(C3-C7cycloalkylene)-portion of the group linked to the nitrogen to which they are connected to form a saturated cycle of up to 6 ring atoms; RL is at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl or C3-C6 cycloalkyl being optionally substituted by a C1-C3 alkyl group, —ORM, —CN, or halo; RM is at each occurrence independently hydrogen, C1-C6 alkyl, or C3-C6 cycloalkyl, said C1-C6 alkyl or C3-C6 cycloalkyl being optionally substituted by hydroxyl, —CN, or halo; z1, z2, z3, and z4 are independently C, N, S, O, a group —CH—, or a group —NH—, in such a combination that the resulting ring formed is an aromatic system; R19 is hydrogen, —CF3, —NRERF, —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), aryl, or heteroaryl wherein any of said —(C3-C7cycloalkyl), —(C3-C7heterocycloalkyl), aryl, or heteroaryl may be optionally substituted by a C1-C6 alkyl group, C3-C7 cycloalkyl group, or halo; or R19 is a group of formula (V) wherein R20, R21, RE and RF are as above defined; T is —N═ or —CR23═; R23 is H, halo, —CH3, or —CN; R22 is H, halo, —CH3, or —CN; q is 0, 1, 2, or 3; with the proviso that when Y is —O(CR3R4)n—, n is 1, and R10 is —NRARB, —N(RC)C(O)—(C1-C6alkylene)-NRARB, —N(RC)C(O)—(C3-C7cycloalkylene)-NRARB, —N(RC)C(O)N(RARB), —N(RC)C(O)N(RC)—(C2-C6alkylene)-NRARB, —N(RC)C(O)N(RC)—(C3-C7cycloalkylene)-NRARB, or —N(RC)C(O)RC, then X1 is nitrogen. |
