METHOD FOR STORING AN EMULSION-ADJUVANTED VACCINE IN A LUBRICATED MEDICAL INJECTION DEVICE

摘要

The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method comprising: (a) providing a medical injection device (1) comprising a barrel (2) having an inner surface (21); (b) forming a silicone oil layer on at least a part of the inner surface (21) of the barrel that is intended to be in contact with the vaccine, (c) carrying out an oxidizing plasma treatment of said layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating (5), (d) filling the barrel with the emulsion-adjuvanted vaccine (6). The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating (5) in a medical injection device (1) comprising a barrel (2), for preventing migration of silicone from said lubricant coating (5) to an emulsion-adjuvanted vaccine (6) during storage of said vaccine in said medical injection device.