BIOLOGICALLY ACTIVE COMPLEX AND ITS PREPARATION

摘要

A biologically active complex comprising either a polypeptide having the sequence of a variant of a naturally occurring protein, wherein said polypeptide is at least partially unfolded as compared to the said naturally occurring protein; or a peptide of up to 50 amino acids, for instance a fragment of the naturally occurring protein or a variant thereof; and a pharmaceutically acceptable salt of a fatty acid or lipid. The complexes of the invention demonstrate a novel mode of action, which gives rise to opportunities for the development of further active agents and screening methods.

主权项

1. A biologically active complex comprising a peptide comprising the sequence LDDDITDDIMXAKKILDIKGIDYWLAHKALXTEKLEQWLXEKL (SEQ ID NO: 4), wherein X is an amino acid residue other than cysteine and the peptide is up to 50 amino acids in length; and a pharmaceutically acceptable salt of a fatty acid or lipid.