发明名称 COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
摘要 The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
申请公布号 US2015344511(A1) 申请公布日期 2015.12.03
申请号 US201314654086 申请日期 2013.12.19
申请人 BLEND THERAPEUTICS, INC. 发明人 Bilodeau Mark T.;Dunbar Craig A.;Barder Timothy E.;Lee Edward R.;Alargova Rossitza G.;Rockwood Danille N.;Shinde Rajesh;Soo Patrick Lim;Moreau Benoît
分类号 C07F15/00;A61K9/51 主分类号 C07F15/00
代理机构 代理人
主权项 1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: two of R1, R2, R3, and R4 each is a halide; the remaining two of R1, R2, R3, and R4 each is independently ammonia or an amine; and R5 and R6 each independently is hydrogen, R7, or wherein:X is absent, C(R8)2, O, S, or NR8, andR7 and R8 independently at each occurrence is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl groups optionally is substituted with one or more groups, each independently selected from halogen, cyano, nitro, hydroxyl, ester, ether, alkoxy, aryloxy, amino, amide, carbamate, alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocyclyl, phosphono, phosphate, sulfide, sulfinyl, sulfino, sulfonyl, sulfo, and sulfonamide, wherein each of the ester, ether, alkoxy, aryloxy, amino, amide, carbamate, alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocyclyl, phosphono, phosphate, sulfide, sulfinyl, sulfino, sulfonyl, sulfo, and sulfonamide is optionally substituted with one or more suitable substituents.
地址 Watertown MA US