EXPANDABLE GASTRORETENTIVE DOSAGE FORM

摘要

An oral gastro-retentive delivery device is provided which unfolds rapidly upon contact with gastric juice. The device is configured in a collapsed configuration for oral intake and unfolding for gastric retention for a predetermined period of time and eventually reducing in size for passage through the rest of the GI track.

主权项

1. A gastroretentive dosage form (GRDF) for extended retention in a stomach, comprising:
a body configured to transform between a collapsed configuration for ingestion, an expanded configuration for retention within the stomach and a third configuration wherein after a predetermined time period has elapsed, the GRDF disassembles into two or more parts such that each of the disassembled parts of the GRDF is sized for exiting the stomach; and an active pharmaceutical ingredient (API) or diagnostic, wherein the third configuration is induced by at least a partial release of the API or diagnostic.