| 摘要 |
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the TWEAKR (TNFRSF12A, FN14). The antibodies, accordingly, can be used to treat tumors and other disorders and conditions associated with expression of the TWEAKR. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for us. |
| 申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT |
发明人 |
VOTSMEIER, CHRISTIAN;HAMMER, STEFANIE;GRITZAN, UWE;BERNDT, SANDRA;ZUBOV, DMITRY;LINDEN, LARS;CHRISTIAN, SVEN;HARRENGA, AXEL;BIRKENFELD, JORG;FREIBERG, CHRISTOPH;GOLFIER, SVEN;EICKER, ANDREA;GREVEN, SIMONE;STELTE-LUDWIG, BEATRIX;RASCHKE, MARIAN |
