发明名称 |
Method of modifying a specific lysine |
摘要 |
The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a) providing a polypeptide comprising a target lysine residue protected by a first protecting group, and at least one further lysine residue; (b) treating the polypeptide to protect said further lysine residue(s), wherein the protecting group for said further lysine residues is different to the protecting group for the target lysine residue; (c) selectively deprotecting the target lysine residue; and (d) modifying the deprotected lysine residue of (c). |
申请公布号 |
EP2550290(B1) |
申请公布日期 |
2015.12.02 |
申请号 |
EP20110715594 |
申请日期 |
2011.03.23 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
CHIN, JASON;VIRDEE, SATPAL |
分类号 |
C12P21/02;C07K1/06;C07K1/107 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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