The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
申请公布号
EP2949752(A2)
申请公布日期
2015.12.02
申请号
EP20150164722
申请日期
2009.09.22
申请人
RXI PHARMACEUTICALS CORPORATION
发明人
KHVOROVA, ANASTASIA;SALOMON, WILLIAM;KAMENS, JOANNE;SAMARSKY, DMITRY;WOOLF, TOD M.;CARDIA, JAMES
