发明名称 |
ASTER GLEHNI FRACTIONS OR COMPOUNDS ISOLATED THEREFROM HAVING ANTI-INFLAMMATORY ACTIVITY |
摘要 |
The present invention relates to an Aster glehni fraction having excellent anti-inflammatory activity and an active compound isolated therefrom. The present invention provides an ethyl acetate fraction of Aster glehni and an active compound isolated from the fraction, where 6′-O-caffeoylroseoside, 6′-O-caffeoyldihydrosyringin and glehnoside have an antioxidant effect due to a strong free radical scavenging ability and simultaneously inhibit generation of pro-inflammatory cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β) which are inflammatory metabolite induced by lipopolysaccharide (LPS), thereby being usefully used as an active component of medicines, cosmetics and health foods needed in treating, preventing and improving inflammatory diseases. |
申请公布号 |
KR20150135036(A) |
申请公布日期 |
2015.12.02 |
申请号 |
KR20140121177 |
申请日期 |
2014.09.12 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
KIM, HYOUNG JA;JIN, CHANG BAE;SON, MIN JEOUNG;LEE, YONG SUP;YOOK, CHANG SOO;LEE, KYUNG TAE;LEE, JAE YEOL |
分类号 |
A61K31/7034;A61K36/28;A61P29/00 |
主分类号 |
A61K31/7034 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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