Immunogenic composition

摘要

The invention provides immunogenic polysaccharide protein conjugates comprising capsular polysaccharides from N. Meningitidis serogroup X and methods for preparation thereof. The present invention relates to N. meningitidis X saccharide-carrier protein conjugates prepared by a conjugation reaction. Accordingly, the instant invention relates to multivalent meningococcal polysaccharide protein conjugate composition comprising capsular saccharide from serogroups X and at least one capsular saccharide from A, C, W135 and Y wherein, i) polysaccharides A C W135 X are sized mechanically whereas polysaccharide Y is sized chemically, ii) all saccharide are conjugated to carrier protein via a linker with a cyanylation conjugation chemistry iii) all saccharide to protein ratios in final conjugates are between 0.2-0.6 and iv) at least two different carrier proteins selected from the group consisting of TT, DT and CRM197 are utilized.

主权项

1. An immunogenic composition comprising
(a) a conjugate of (i) the capsular saccharide of serogroup A N. meningitidis and (ii) tetanus toxoid; (b) a conjugate of (i) capsular saccharide of serogroup C N. meningitidis and (ii) CRM197; (c) a conjugate of (i) capsular saccharide of serogroup Y N. meningitidis and (ii) CRM197; (d) a conjugate of (i) capsular saccharide of serogroup W135 N. meningitidis and (ii) CRM197; and (e) a conjugate of (i) capsular saccharide of serogroup X N. meningitidis and (ii) tetanus toxoid wherein the N. meningitidis X polysaccharide-protein conjugate is derived from N. meningitidis X strain 8210, 9601, 9592, 9554 or 2526.